Henrietta Rose-Innes (born 14 September 1971) is a South African novelist and short-story writer. She was the 2008 winner of the Caine Prize for African Writing for her speculative-fiction story "Poison". Her novel Nineveh was shortlisted for the 2012 Sunday Times Prize for Fiction and the M-Net Literary Awards. In September of that year her story "Sanctuary" was awarded second place in the 2012 BBC (Inter)national Short Story Award.
Rose-Innes has been a Fellow in Literature at the Akademie Schloss Solitude, Stuttgarteco (2007–08) and has held residencies at the Rockefeller Foundation's Bellagio Center; Chateau de Lavigny, Lausanne; the kunst:raum sylt quelle, Sylt; Georgetown University; the University of Cape Town's Centre for Creative Writing; Caldera Arts Center, Oregon; and Hawthornden Castle Writer's Retreat, Scotland. She is a 2012 Gordon Fellow at the Gordon Institute for Creative and Performing Arts (GIPCA), University of Cape Town. She is currently studying towards a PhD in Creative Writing at the University of East Anglia.