In the tradition that includes Emmanuel Lévinas and Paul Ricoeur, Jean-Louis Chrétien starts from the premise that there is no human act, even the happiest and most empowering, that does not arise on the horizon of fatigue. From fatigue, then, he formulates a thought about lassitude, listlessness, weariness and exhaustion as ways of being in the world. Crossing philosophy and literature –Nietzsche and Pessoa, Simone Weil and Mallarmé– Chrétien investigates the phenomenon of fatigue in three fundamental figures: Greek fatigue, biblical fatigue of the Judeo-Christian tradition, and nihilistic fatigue. Intertwined with each other, these aspects of fatigue will raise the most unusual questions about our relationship with the body, with time, with death, but also with the divine and tireless.