In The Blood of the Lamb, Wanderhope, the author's alter ego, tells us what his life has been like since his childhood in Chicago, in a Calvinist family, until the death of his 12-year-old daughter, sick with leukemia. A life, then, marked by the loss: that of his brother, that of his first love, that of his suicidal wife and finally that of his daughter. However, far from turning him into a defeated and mute being, the constant presence of death leads Wanderhope to wonder about the meaning of everything in a tone in which anger and mourning keep mingling with ingenuity, humor and tenderness. The blood of the lamb offers us an exhibition of wit, lyricism, verbal precision and comics that confirms De Vries as one of the best American writers of the 20th century.