Pursued by the Inquisition, expelled from Lisbon, Antwerp, Venice and Ferrara in succession, the extraordinary destiny of La Madame traces a luminous path across the whole of 16th century Europe, culminating in an apotheosis in the Ottoman Empire. Real name Gracia Nasí, this young and seductive heiress of an immense fortune, enemy of the Habsburgs, the popes and the Republic of Venice, still embodies today the pride and pain of the Marranos, those Jews forced to convert, those "new Christians", for whom she became a legendary figure, and whose epic and novelistic existence is restored by Catherine Clément.

In the heart of the West, torn by religious hatred and political conflict, she will organize networks destined to the escape of the persecuted and the victims of intolerance. Before paying dearly for the protection of Istanbul, she sponsored the Ferrara Bible, the first Bible in Judeo-Spanish, a magnificent emblem that would be dedicated to her and would make her go down in history.

The Lady and her nephew are the protagonists of this flamboyant fresco in which love affairs and theological disputes, initiation into political power and great events of the time are mixed. A true novel, but also a tale, an epic, The Lady is also a prayer, a love song, a memorial.