In September 2017, two powerful earthquakes struck, causing loss of life, injuries, displacement, material damage, and the destruction of heritage monuments in several states of Mexico. The organization, rescue efforts, and support provided by the government and civil society in response to the disaster were swift and effective, but short-lived. The reconstruction of damaged buildings and cultural heritage will take many more years. This manual for the rescue of heritage collections in the event of a natural disaster, focusing on mural painting, stems from brigades organized by the Institute of Aesthetic Research to assess and document the damage caused by the 2017 earthquakes to cultural heritage, and from a project to rescue mural paintings in convents along the Volcano Route. The text aims to guide actions and strategies for recovering and intervening in collapsed movable and immovable property and is intended for those responsible for heritage preservation, as well as civil and religious organizations. It also presents the case studies of the murals of San Juan Bautista Tlayacapan and San Guillermo Totolapan, convent complexes in the state of Morelos.