The text we present today—and which has traditionally been attributed to Aristotle—although small in size, is at the origin of a vast and fruitful literature that has interrogated the relationship between melancholy and creativity. Men of genius, great creators—it is asked—aren't they precisely among the depressive and the melancholic? Problem XXX, entitled here The Man of Genius and Melancholy, has preoccupied physicians and philosophers from Antiquity to the present day, illuminating both the "melancholy" of the ancients and the "spleen" of the moderns, in a journey of fascinating and fruitful exploration.