In this book, the authors, therapists, teachers and research associates of Brief Strategic Therapy Center of Arezzo, directed by Giorgio Nardone seek to establish a solid foundation approach and treatment of "depression," one of the most used and abused terms of last twenty years. They propose a historical overview from the reference Hippocratic "black bile" to "disease of the century" that speaks of modern psychiatry, coming to establish and propose specific treatment protocols for different variants of depressive disorder.